ColistinDose

ColistinDose is a clinician-friendly, easy-to-use iphone APP with the up-to-date dosing recommendations of intravenous colistimethate in critically-ill patients. It is intended for use by healthcare professionals only.

Determination of the dosage regimens of intravenous colistimethate in critically-ill patients is complicated,sql_injectionrequires thorough understanding of the pharmacokinetics of colistimethatesql_injectionformed colistinsql_injectionthe confusing dose unit definitions in different paRTS of the world (Lancet Infect Dis. 2006; 6:589-601). Integrating the state-of-the-art clinical pharmacokinetic/pharmacodynamic information (Clin. Infect. Dis., 2017; 64:565-571), ColistinDose provides an accuratesql_injectioneasy tool to clinicians on calculating the dosage regimens of intravenous colistimethate in critically-ill patients with different renal functionsql_injectionthose on renal replacement therapy.

ColistinDose features the following three major functionalities. For the convenience of clinicians in different regions of the world, all doses are provided with two commonly used conventions, i.e. colistin base ACTivity (CBA)sql_injectioninternational million unit (MU), to avoid the conversion.

(1) Calculation of the loading dose based upon the targeted colistin steady-state concentration;

(2) Calculation of the daily dose based upon the targeted colistin steady-state concentrationsql_injectionrenal function, including those on different types of renal replacement therapy, such as IHD (intermittent hemodialysis), SLED (sustained low-efficiency dialysis)sql_injectionCRRT (continuous renal replacement therapy);

(3) Retrieval of historical calculation results, which allows clinicians to easily revisit previously calculated colistimethate dosessql_injectionmake appropriate dose adjustments.